祁宏，教授，应用数学专业博士生导师、应用统计专业硕士生导师。2014年9月毕业于厦门大学理论物理专业，12月进入山西大学复杂系统研究所工作。拥有跨学科背景，涵盖生物学、物理学、数学和计算机科学等多个领域，擅长数据可视化，对数学魔术有深入研究。主持科技项目6项(其中国家级项目3项)，参与重点项目1项。发表文章44篇 (其中SCI论文30篇)，被引用800余次；参与出版著作一部。

所授课程： 大数据分析计算机基础、生物系统的时空分析 (授课对象：研究生)
                 科研作图与数据可视化 (授课对象：本科生，山西大学通识教育精品课程)

B站链接： https://space.bilibili.com/478308849

研究方向： 计算系统生物学、机器学习、数据可视化

学术任职： 中国工业与应用数学学会 数学生命科学专业委员会 委员
               
主持项目：
1. 国家自然科学基金面上项目：线粒体膜完整性调控细胞命运的动力学机制研究；项目编号：12275164；执行期限：2023.01-2026.12；金额：55万。
2. 国家自然科学基金数学天元基金项目：前馈环与反馈环耦合网络多稳态行为研究；项目编号：12226317；执行期限：2023.01-2023.12；金额：10万。(访问学者项目，访学单位：北京大学)
3. 国家自然科学基金青年科学基金项目：胞质钙信号调控细胞凋亡的动力学机制研究；项目编号：11504214；执行期限：2016.01-2018.12；金额：22.28万。
4. 山西省高等学校科技创新项目：线粒体通透性转换孔开放导致细胞死亡的机制；项目编号：2019L0015；执行期限：2019.07-2021.07；金额：3万。
5. 山西省青年科技研究基金面上青年基金项目：Bcl-2蛋白通过钙信号调控细胞凋亡的数学建模与分析；项目编号：201901D211159；执行期限：2019.09-2022.09；金额：3万。
6. 温州市生物物理重点实验室开放基金：Bcl-2蛋白家族在炎症和癌症发生中作用的理论研究；项目编号：WIUCASSWWL22003；执行期限：2022.05-2024.05；金额：5万。

研究生：
2024级博士： 尹钰淞

2024级硕士： 崔鹏飞、赵瑞、张子珺、陶瑞敏、王文静、赵显晶
2023级硕士： 吕锋、南心雨、高志学、董文晓、赵若兰
2022级硕士： 曹旭清、尹钰淞、马中琳  
2021级硕士： 王洋、安致远  
2020级硕士： 孙长君  
2019级硕士： 史志强、李智超、李爱莎
2017级硕士： 庞兴慧、许国平  
2015级硕士： 牛帅


出版书籍：
雷锦志, 易鸣, 杨凌, 刘锐, 祁宏. 《系统生物学》, 科学出版社, 2024.

发表论文 (Publications, Corresponding author*, Co-first authour^#)：
Researcher ID in Web of Science    http://www.researcherid.com/rid/D-2944-2014
ORCID iD     https://orcid.org/0000-0003-2230-1763

44. Fei Xu, Xiang Li*, Rui Wu, Hong Qi, Jun Jin, Zhilong Liu, Yuning Wu, Hai Lin, Chuansheng Shen, Jianwei Shuai*. Incoherent feedforward loop dominates the robustness and tunability of necroptosis biphasic, emergent, and coexistent dynamics [J]. Fundamental Research, 2024.  (Link) {IF=6.2} <Cited by 1>

43. 祁 宏*, 马中琳, 曹旭清. 前馈环与反馈环的动力学行为研究进展[J]. 山西大学学报(自然科学版)，2024, 47(04): 717-726.  (Link)

42. 祁 宏*,  王洋, 石艳香. 细胞凋亡、坏死和焦亡信号网络关键节点的识别[J]. 河南师范大学学报(自然科学版), 2024, 52(1): 51-59. (Link)   <Cited by 2>

41. Jun Jin, Fei Xu#, Zhilong Liu, Hong Qi, Chenggui Yao, Jianwei Shuai, and Xiang Li*. Biphasic amplitude oscillator characterized by distinct dynamics of trough and crest [J]. Physical Review E, 2023, 108: 064412. (Link) {IF=2.71，SCI三区}   <Cited by 17>

40. Bojie Yang, Zhuoqin Yang*, Heng Liu, Hong Qi*. Dynamic modelling and tristability analysis of misfolded α-synuclein degraded via autophagy in Parkinson's disease [J]. Biosystems, 2023, 233: 105036. (Link) {IF=1.6，SCI四区，T2期刊}   <Cited by 3>

39. Hong Qi*, Yu-Song Yin, Zhi-yong Yin, Xiang Li, Jian-wei Shuai. Mitochondrial outer membrane permeabilization and inner membrane permeabilization in regulating apoptosis and inflammation [J]. Journal of Theoretical Biology, 2023, 571: 111558. (Link) {IF=2.0，SCI三区，T2期刊}   <Cited by 3>

38. Xiang Li*, Pei-pei Zhang, Zhiyong Yin, Fei Xu, Zhanghua Yang, Jun Jin, Jing Qu, Zhilong Liu, Hong Qi, Chenggui Yao, Jianwei Shuai*. Caspase-1 and Gasdermin D Afford the Optimal Targets with Distinct Switching Strategies in NLRP1b Inflammasome-Induced Cell Death [J]. Research, 2022. (Link) {IF=11.04, Science Partner Journal} <Cited by 75>

37. Li Gao*, Wu-yan Yang, Hong Qi, Chang-Jun Sun, Xue-mei Qin, Guan-hua Du*. Unveiling the anti-senescence effects and senescence-associated secretory phenotype (SASP) inhibitory mechanisms of Scutellaria baicalensis Georgi in low glucose-induced astrocytes based on boolean network [J]. Phytomedicine, 2022, 99: 153990.  (Link) {IF=6.66，SCI二区top}  <Cited by 6>

36. 祁 宏*, 李智超, 史志强. 线粒体膜完整性对细胞命运的调控[J]. 生物化学与生物物理进展，2022，49 (9): 1638-1647. (Link) {Progress in Biochemistry and Biophysics, IF=0.351, SCI三区} <Cited by 7>

35. Ligang Zhu, Xiang Li*, Fei Xu, Zhiyong Yin, Jun Jin, Zhilong Liu, Hong Qi, Jianwei Shuai*. Network modeling-based identification of the switching targets between pyroptosis and secondary pyroptosis [J]. Chaos, Solitons & Fractals, 2022, 155: 111724. (Link){IF=9.92，SCI一区} <Cited by 10>

34. Xiao-Long Peng, Chun-Yan Li, Hong Qi, Gui-Quan Sun, Zhen Wang*, Yong-Ping Wu*. Competition between awareness and epidemic spreading in homogeneous networks with demography [J]. Applied Mathematics and Computation, 2022, 420: 126875. (Link) {IF=4.397，SCI一区} <Cited by 5>

33. Hong Qi*, Zhi-Chao Li, Shi-Miao Wang, Lin Wu, Fei Xu, Zhi-Long Liu, Xiang Li*, Jia-Zeng Wang*. Tristability in mitochondrial permeability transition pore opening [J]. Chaos, 2021, 31(12): 123108. (Link) {IF=3.74，SCI二区，T2期刊} <Cited by 10>

32. Hong Qi(祁宏)*, Zhi-Qiang Shi(史志强), Zhi-Chao Li(李智超), Chang-Jun Sun(孙长君), Shi-Miao Wang(王世苗), Xiang Li(李翔), Jian-Wei Shuai(帅建伟)*. Dual mechanisms of Bcl-2 regulation in IP3-receptor-mediated Ca2+ release: A computational study [J]. Chinese Physics B, 2021, 30(10): 108704. (Link) {IF=1.65，SCI三区；本期亮点文章} <Cited by 3>

31. Zhiyong Yin, Pei-pei Zhang#, Fei Xu, Zhilong Liu,Ligang Zhu, Jun Jin, Hong Qi, Jianwei Shuai*, Xiang Li*. Cell death modes are specified by the crosstalk dynamics within pyroptotic and apoptotic signaling [J]. Chaos, 2021, 31(9): 093103. (Link) {IF=3.74，SCI二区，T2期刊}   <Cited by 1>

30. Xiang Li, Jun Jin, Xiaocui Zhang, Fei Xu, Jinjin Zhong,Zhiyong Yin, Hong Qi, Zhaoshou Wang*, Jianwei Shuai*. Quantifying the optimal strategy of population control of quorum sensing network in Escherichia coli [J]. npj Systems Biology and Applications, 2021, 7(1): 35. (Link) {IF=4.67，SCI二区} <Cited by 18>

29. Wen Liu, Xiang Li, Hong Qi, Yuning Wu, Jing Qu, Zhiyong Yin, Xuejuan Gao, Aidong Han, Jianwei Shuai*. Biphasic regulation of transcriptional surge generated by the gene feedback loop in a two-component system [J]. Bioinformatics, 2021, 37(17): 2682–2690. (Link) {IF=6.937，SCI二区Top} <Cited by 12>

28. 李翔, 祁 宏, 黄艳东，帅建伟*. 钙离子信号及细胞调控信号网络动力学[J]. 中国科学:物理学 力学 天文学, 2021, 51(03): 030010. (Link) {一级学科主学报} <Cited by 11>

27. Xiang Li, Chuan-Qi Zhong, Rui Wu, Xiaozheng Xu, Zhang-Hua Yang, Shaowei Cai, Xiurong Wu, Xin Chen, Zhiyong Yin, Qingzu He, Dianjie Li, Fei Xu, Yihua Yan, Hong Qi, Changchuan Xie, Jianwei Shuai*,  Jiahuai Han*. RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes [J]. Protein & Cell, 2021, 12(11): 858-876. (Link) {IF=21.1，SCI一区} <Cited by 97>

26. Hong Qi*, Guoping Xu, Xiao-Long Peng, Xiang Li, Jianwei Shuai, Rui Xu*. Roles of four feedback loops in mitochondrial permeability transition pore opening induced by Ca2+ and reactive oxygen species [J]. Physical Review E, 2020, 102(6): 062422. (Link) 【中文简介】 {IF=2.71，SCI三区} <Cited by 12>

25. Hong Qi*, Xiang Li, Zhen Jin, Thomas Simmen, Jianwei Shuai*. The oscillation amplitude, not the frequency of cytosolic calcium, regulates apoptosis induction [J]. iScience, 2020, 23(11): 101671. (Link) 【中文简介】{IF=6.12, SCI二区, Cell 出版社 Research Journal} <Cited by 23>

24. Xiang Li, Hong Qi, Xiao-Cui Zhang, Fei Xu, Zhi-yong Yin,Shi-Yang Huang, Zhao-Shou Wang, Jianwei Shuai*. Quantitative modeling of bacterial quorum sensing dynamics in time and space [J]. Chinese Physics B, 2020, 29(10): 108702. (Link) {IF=1.65，SCI三区} <Cited by 3>

23. Tomás Gutiérrez, Hong Qi, Megan C. Yap, Nasser Tahbaz, Leanne A. Milburn, Eliana Lucchinetti, Phing-How Lou, Michael Zaugg, Paul G. LaPointe, Pascal Mercier, Michael Overduin, Helmut Bischof, Sandra Burgstaller, Roland Malli, Klaus Ballanyi, Jianwei Shuai, Thomas Simmen*. The ER chaperone calnexin controls mitochondrial positioning and respiration [J]. Science Signaling, 2020, 13(638): eaax6660. (Link) {IF=9.52，Science 子刊；封面文章，实验和理论结合研究} <Cited by 48>

22. Xiang Li, Chuan-Qi Zhong, Zhiyong Yin, Hong Qi, Fei Xu, Qingzu He, Jianwei Shuai*. Data-Driven Modeling Identifies TIRAP-Independent MyD88 Activation Complex and Myddosome Assembly Strategy in LPS/TLR4 Signaling [J]. International Journal of Molecular Sciences, 2020, 21(9): 3061.  (Link) {IF=6.21，SCI二区Top}  <Cited by 29>

21. 庞兴慧, 祁 宏*. 改进的De Young-Keizer钙振荡模型[J]. 江西师范大学学报(自然科学版)，2019，6: 613-619. (Link) {中文核心期刊} <Cited by 1>

20. 庞兴慧, 祁 宏*. 基于钙响应钟型曲线构建的钙振荡模型[J]. 厦门大学学报(自然科学版)，2019，58(4): 574-581. (Link) {中文核心期刊} <Cited by 1>

19. 许国平，杨鹏, 祁 宏*. Bcl-2蛋白家族调节凋亡和自噬信号通路的研究进展[J]. 中国细胞生物学学报，2019，41(6): 1127-1134. (Link) {一级学科主学报} <Cited by 74>

18. 牛帅，孙小强, 祁 宏*. 改进双钙库模型的分岔分析[J]. 中山大学学报(自然科学版)，2018，57(5): 132-139. (Link) {二级学科主学报} <Cited by 5>

17.Hong Qi, Yu Jiang, Zhiyong Yin, Ke Jiang, Linxi Li, Jianwei Shuai*. Optimal pathways for the assembly of the Apaf-1·cytochrome c complex into apoptosome [J]. Physical Chemistry Chemical Physics, 2018, 20: 1964-1973.  (Link) 【中文简介】 {IF=4.449，SCI二区Top} <Cited by 33>

16. 牛帅，帅建伟*, 祁 宏*. Bcl-2蛋白抑制钙信号的建模与全局动力学分析[J]. 物理学报，2017, 66(23): 238701. (Link) {Acta Physica Sinica, IF=0.624，SCI四区；《物理学报》当期推荐文章} <Cited by 10>

15. Xiang Li, Jingjing Zhong, Xuejuan Gao, Yuning Wu, Jianwei Shuai, Hong Qi*. Biexponential distribution of open times of a toy channel model [J]. Chinese Physics B, 2017, 26(12): 128703. (Link) {IF=1.436，SCI三区} <Cited by 2>

14. Zhiyong Yin, Hong Qi^#, Lili Liu, Zhen Jin*. The optimal regulation mode of Bcl-2 apoptotic switch revealed by bistability analysis [J]. BioSystems, 2017, 162: 44-52. (Link) {IF=1.96，SCI四区} <Cited by 21>

13. 尹智勇，杨俊元，祁 宏*. Bcl-2蛋白质家族调控细胞凋亡机制的研究进展[J]. 信阳师范学院学报(自然科学版)，2017, 30(2): 340-344. (Link) {中文核心期刊} <Cited by116> 【学报引用排行榜第一】

12. Xiuhong Cai, Xiang Li, Hong Qi, Fang Wei, Jianyong Chen and Jianwei Shuai*. Comparison of gating dynamics of different IP3R channels with immune algorithm searching for channel parameter distributions [J]. Physical Biology, 2016, 13(5): 056005.  (Link) {IF=2.96，SCI三区} <Cited by 6>

11. Yuan Chen, Hong Qi, Xiang Li, Meichun Cai, Xingqiang Chen, Wen Liu, and Jianwei Shuai*. Suppressing effect of Ca2+ blips on puff amplitudes by inhibiting channels to prevent recovery [J]. Physical Review E, 2016, 94: 022411.  (Link) {IF=2.252，SCI三区} <Cited by 6>

10. Xiang Li, Yuan Chen, Hong Qi, Liyu Liu, Jianwei Shuai*. Synonymous mutations in oncogenesis and apoptosis versus survival unveiled by network modeling [J]. Oncotarget, 2016, 7(23): 34599-34616.  (Link) {IF=5.008，SCI一区} <Cited by 12>

9. 陈 圆，祁 宏，李 翔，帅建伟*. 钙离子通道和钙信号震荡模型研究[J]. 生物物理学，2016, 4(1): 1-26. (Link)

8. Hong Qi*, Jianwei Shuai*. Alzheimer's disease via enhanced calcium signaling caused by the decrease of endoplasmic reticulum–mitochondrial distance [J]. Medical Hypotheses, 2016, 89: 28–31.  (Link)【中文简介】{IF=4.7，SCI四区} <Cited by 26>

7. Hong Qi, Linxi Li, and Jianwei Shuai*. Optimal microdomain crosstalk between endoplasmic reticulum and mitochondria for Ca2+ oscillations [J]. Scientific Reports, 2015, 5: 7984.  (Link) {IF=5.578，SCI二区} <Cited by 85>

6. Hong Qi, Yandong Huang, Sten Rüdiger, and Jianwei Shuai*. Frequency and relative prevalence of calcium blips and puffs in a model of small IP3R clusters [J]. Biophysical Journal, 2014, 106(11): 2353-2363.  (Link) {IF=3.972，SCI二区Top} <Cited by 20>

5. 祁 宏，帅建伟*. IP3R钙离子通道集团中的blip动力学[J]. 中国科技论文，2013, 8(6): 534-537. {中文核心期刊} <Cited by 2>

4. 祁 宏，刘丽仙，袁峰，李大林，袁跃云，苗永旺. 水牛κ-酪蛋白基因(CSN3)外显子4序列多态性研究[J]. 家畜生态学报，2012，33(2): 13-19. {中文核心期刊} <Cited by 4>

3. 祁 宏，李卫真，袁峰，李大林，刘丽仙，钱坤，苗永旺. 水牛β-LG基因3,4外显子遗传特性分析[J]. 云南农业大学学报，2011, 26(1): 34-40. {中文核心期刊} <Cited by 1>

2. 祁 宏，苗永旺. 牛κ-酪蛋白基因变异及其与奶用性状的关系[J]. 中国牛业科学，2010, 36(4): 51-55.

1. 祁 宏，苗永旺. 牛αS1酪蛋白基因变异及其与生产性状的关系[J]. 中国牛业科学，2009, 35(4): 39-42. <Cited by 8>

Last modified: Nov. 12th, 2024